NAV 2729

Name: NAV 2729
Brand: Tocris Bioscience
SKU: 5986

Tocris Bioscience, part of Bio-Techne | Catalog # 5986

Citations (14)

COA / SDS

Selective ARF6 inhibitor

Key Product Details

Description:	Selective ARF6 inhibitor
Chemical Name:	3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	456.88

View Full Technical Details for NAV 2729

Technical Data
Citations

Biological Activity for NAV 2729

NAV 2729 is a selective ARF6 inhibitor (IC₅₀ = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

Compound Libraries for NAV 2729

NAV 2729 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NAV 2729

M. Wt	456.88
Formula	C₂₅H₁₇ClN₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	419547-11-8
PubChem ID	2257249
InChi Key	WHYGBVWGARJOCS-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C2=C3NC(C4=CC=C([N+]([O-])=O)C=C4)=CC(N3N=C2CC5=CC=CC=C5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NAV 2729

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.69	100

Preparing Stock Solutions for NAV 2729

The following data is based on the product molecular weight 456.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.94 mL	21.89 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for NAV 2729

References are publications that support the biological activity of the product.

Yoo ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma. Cancer Cell. 2016 PMID: 27265506