Phenyl-glutarimide 4'-oxyacetic acid

Name: Phenyl-glutarimide 4'-oxyacetic acid
Brand: Tocris Bioscience
SKU: 7670

Tocris Bioscience, part of Bio-Techne | Catalog # 7670

COA / SDS

Functionalized cereblon ligand for PROTAC development

Key Product Details

Description:	Functionalized cereblon ligand for PROTAC development
Chemical Name:	2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
Purity:	≥95% (HPLC)
Molecular Weight:	263.25

View Full Technical Details for Phenyl-glutarimide 4'-oxyacetic acid

Technical Data
Citations

Biological Activity for Phenyl-glutarimide 4'-oxyacetic acid

Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC^® Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Phenyl-glutarimide 4'-oxyacetic acid

M. Wt	263.25
Formula	C₁₃H₁₃NO₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2782024-58-0
InChi Key	AJINEEJVZAYBCQ-UHFFFAOYSA-N
Smiles	O=C(N1)CCC(C2=CC=C(C=C2)OCC(O)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Phenyl-glutarimide 4'-oxyacetic acid

References are publications that support the biological activity of the product.

Min Phenyl-glutarimides: alternative cereblon binders for the design of PROTACs. Angew.Chem.Int.Ed. 2021 PMID: 34614283