TL 13-112

Name: TL 13-112
Brand: Tocris Bioscience
SKU: 6745

Tocris Bioscience, part of Bio-Techne | Catalog # 6745

Citations (3)

COA / SDS

Selective ALK Degrader (PROTAC®)

Key Product Details

Description:	Selective ALK Degrader (PROTAC^®)
Chemical Name:	N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	1002.57

View Full Technical Details for TL 13-112

Technical Data
Citations

Biological Activity for TL 13-112

TL 13-112 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC^®) (DC₅₀ values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h.

Negative control TL 13-110 (Cat. No. 6746), and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for TL 13-112

M. Wt	1002.57
Formula	C₄₉H₆₀ClN₉O₁₀S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2229037-19-6
Smiles	CC(OC1=CC(C2CCN(CC2)CCOCCOCCNC(CNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)=C(C=C1NC6=NC=C(C(NC7=CC=CC=C7S(=O)(C(C)C)=O)=N6)Cl)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TL 13-112

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.13	50

Preparing Stock Solutions for TL 13-112

The following data is based on the product molecular weight 1002.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.99 mL	9.97 mL	19.95 mL
2.5 mM	0.40 mL	1.99 mL	3.99 mL
5 mM	0.20 mL	1.00 mL	1.99 mL
25 mM	0.04 mL	0.20 mL	0.40 mL

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References for TL 13-112

References are publications that support the biological activity of the product.

Powell Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 2019 PMID: 29660984