VH 032 amide-alkylC4-acid

Name: VH 032 amide-alkylC4-acid
Brand: Tocris Bioscience
SKU: 6680

Tocris Bioscience, part of Bio-Techne | Catalog # 6680

COA / SDS

VHL ligand with alkyl linker and terminal acid for onward chemistry

Key Product Details

Description:	VHL ligand with alkyl linker and terminal acid for onward chemistry
Alternative Names:	(S,R,S)-AHPC-C4-COOH
Chemical Name:	6-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	558.69

View Full Technical Details for VH 032 amide-alkylC4-acid

Technical Data
Citations

Biological Activity for VH 032 amide-alkylC4-acid

VH 032 amide-alkylC4-acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand plus alkylC4 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 5

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032 amide-alkylC4-acid

M. Wt	558.69
Formula	C₂₈H₃₈N₄O₆S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2172819-74-6
PubChem ID	134183827
InChi Key	DKSZOQIYZOVHOL-TYBLODHISA-N
Smiles	CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCC(O)=O)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032 amide-alkylC4-acid

References are publications that support the biological activity of the product.

Salami Waste disposal-An attractive strategy for cancer therapy. Science 2017 PMID: 28302825
Zengerle Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 2015 PMID: 26035625