VH 032 amide-alkylC4-amine

Name: VH 032 amide-alkylC4-amine
Brand: Tocris Bioscience
SKU: 6465
Rating: 5 (0 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6465

COA / SDS

VHL ligand with alkyl linker and terminal amine for onward chemistry

Key Product Details

Description:	VHL ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names:	(S,R,S)-AHPC-C4-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(5-aminopentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	602.62

View Full Technical Details for VH 032 amide-alkylC4-amine

Technical Data
Citations

Biological Activity for VH 032 amide-alkylC4-amine

VH 032 amide-alkylC4-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 3

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032 amide-alkylC4-amine

M. Wt	602.62
Formula	C₂₇H₃₉N₅O₄S.2HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2341796-78-7
PubChem ID	134160245
InChi Key	QBJGQVIKGJREIR-IYCRVZLISA-N
Smiles	O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)CCCCN.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032 amide-alkylC4-amine

References are publications that support the biological activity of the product.

Salami Waste disposal-An attractive strategy for cancer therapy. Science 2017 PMID: 28302825