Compounds for Stem Cell Differentiation: Small Molecules and Peptides
Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.
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Compounds for Stem Cell Differentiation: Small Molecules and Peptides
Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.
63 results for "Compounds for Stem Cell Differentiation Small Molecules and Peptides" in Products
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
Purity: | ≥99% (HPLC) |
Adenylyl cyclase activator
Chemical Name: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one |
Purity: | ≥98% (HPLC) |
Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs
Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
Purity: | ≥98% (HPLC) |
Potent AMPK inhibitor; also BMP type I receptor inhibitor
Alternate Names: | Compound C,BML-275 |
Chemical Name: | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride |
Purity: | ≥98% (HPLC) |
High affinity PKC activator; also APP modulator
Chemical Name: | (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide |
Purity: | ≥98% (HPLC) |
Endogenous retinoic acid receptor agonist
Alternate Names: | Tretinoin,ATRA |
Chemical Name: | 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid |
Purity: | ≥98% (HPLC) |
Glutathione (GSH) precursor; maintains stem cell function in culture.
Chemical Name: | (2R)-2-Acetamido-3-sulfanylpropanoic acid |
Purity: | ≥98% (HPLC) |
Selective ALK2 inhibitor
Chemical Name: | 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
Purity: | ≥98% (HPLC) |
Anti-inflammatory glucocorticoid
Chemical Name: | (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione |
Purity: | ≥98% (HPLC) |
Histone deacetylase inhibitor
Chemical Name: | Butanoic acid sodium salt |
Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
Chemical Name: | O-(4-Hydroxy-3-iodophenyl-3,5-diiodo-L-tyrosine |
Purity: | ≥98% (HPLC) |
AMPK activator
Chemical Name: | N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
Purity: | ≥99% (HPLC) |
Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs
Chemical Name: | 2-(Dihydrogen phosphate)-L-ascorbic acid sodium salt |
Purity: | ≥95% (HPLC) |
Synthetic retinoid; induces differentiation of stem cells
Chemical Name: | 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid |
Purity: | ≥99% (HPLC) |
Smo receptor agonist
Chemical Name: | 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine |
Purity: | ≥98% (HPLC) |
LDN 193189 synthesized to cGMP guidelines
Chemical Name: | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride |
Purity: | ≥99% |
DAPT synthesized to Ancillary Material Grade
Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester |
Purity: | ≥99% |
Selective JNK inhibitor
Chemical Name: | Anthra[1-9-cd]pyrazol-6(2H)-one |
Purity: | ≥98% (HPLC) |
Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation
Chemical Name: | 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol |
Purity: | ≥97% (HPLC) |
Endogenous agonist of LPA1 and LPA2
Chemical Name: | 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt |
5-HT reuptake inhibitor
Chemical Name: | N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride |
Purity: | ≥99% (HPLC) |
T3 synthesized to Ancillary Material Grade
Chemical Name: | O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine |
Purity: | ≥98% |
Forskolin synthesized to Ancillary Material Grade
Chemical Name: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one |
Purity: | ≥98% |
DNA methyltransferase and cytidine deaminase inhibitor
Alternate Names: | NSC 309132 |
Chemical Name: | 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone |
Purity: | ≥99% (HPLC) |
FGFR1 and -3 inhibitor
Chemical Name: | N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
Purity: | ≥98% (HPLC) |